Article
The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release.
Journal of virology - 1 Sept 2004
Melamed Daniel, Mark-Danieli Michal, Kenan-Eichler Michal, Kraus Osnat, Castiel Asher, Laham Nihay, Pupko Tal, Glaser Fabian, Ben-Tal Nir, Bacharach Eran
Abstract excerpt
The retroviral Gag precursor plays an important role in the assembly of virion particles. The capsid (CA) protein of the Gag molecule makes a major contribution to this process. In the crystal structure of the free CA protein of the human immunodeficiency virus type 1 (HIV-1), 11 residues of the C terminus were found to be unstructured, and to date no information exists on the structure of these residues in the...
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