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Article

Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.

Pharmacogenetics and genomics - 1 Nov 2008

Smith Helen E, Jones J P, Kalhorn Thomas F, Farin Federico M, Stapleton Patricia L, Davis Connie L, Perkins James D, Blough David K, Hebert Mary F, Thummel Kenneth E, Totah Rheem A

Abstract excerpt

OBJECTIVES: The calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus (Tac) help prevent allograft rejection but are associated with nephrotoxicity. Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, promoting kidney homeostasis. This study examined the association between CNI-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18769365
DOI: 10.1097/FPC.0b013e32830e1e16
PMCID: PMC2709795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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