Article
Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors.
Pharmacotherapy - 1 Feb 2010
Bai Jane P F, Lesko Lawrence J, Burckart Gilbert J
Abstract excerpt
The calcineurin inhibitors-cyclosporine and tacrolimus-are the mainstay of immunosuppressive therapy in solid organ transplantation. These drugs produce severe adverse drug effects (ADEs) such as nephrotoxicity, posttransplantation diabetes mellitus, and hypertension. Accumulated evidence suggests that the development of type 2 diabetes, hypertension, and renal failure may be associated with specific DNA...
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