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Article

The pharmacogenetics of calcineurin inhibitor-related nephrotoxicity.

Therapeutic drug monitoring - 1 Aug 2010

Hesselink Dennis A, Bouamar Rachida, van Gelder Teun

Abstract excerpt

Chronic calcineurin inhibitor (CNI)-induced nephrotoxicity is associated with prolonged use of cyclosporine and tacrolimus and has been observed after all types of transplantation, as well as during treatment of autoimmune disease. Extensive alterations in the renal architecture including glomerular sclerosis, tubular atrophy and interstitial fibrosis may lead to end-stage renal failure. Increasing evidence shows...

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Source

Identifiers

PMID: 20571464
DOI: 10.1097/FTD.0b013e3181e44244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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