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Article

Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: results from a kidney transplant consortium.

Transplantation - 27 Mar 2012

Jacobson Pamala A, Schladt David, Israni Ajay, Oetting William S, Lin Yi Cheng, Leduc Robert, Guan Weihau, Lamba Vishal, Matas Arthur J

Abstract excerpt

BACKGROUND: Calcineurin inhibitor (CNI)-related acute nephrotoxicity is a common complication of transplantation. Clinical factors and elevated CNI levels are associated with nephrotoxicity; however, they do not fully explain the risk. Genetic factors may also predispose individuals to nephrotoxicity. METHODS: We enrolled 945 kidney recipients into a multicenter, prospective study. DNA was genotyped for 2724...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22334041
DOI: 10.1097/TP.0b013e3182461288
PMCID: PMC3299910

Genes

GAN
MTRR
PAX4
XPC

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