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Article

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Xiao Bing, Spencer James, Clements Adrienne, Ali-Khan Nadeem, Mittnacht Sibylle, Broceño Cristina, Burghammer Manfred, Perrakis Anastassis, Marmorstein Ronen, Gamblin Steven J

Abstract excerpt

The retinoblastoma tumor suppressor protein (pRb) regulates the cell cycle, facilitates differentiation, and restrains apoptosis. Furthermore, dysfunctional pRb is thought to be involved in the development of most human malignancies. Many of the functions of pRb are mediated by its regulation of the E2F transcription factors. To understand the structural basis for this regulation, we have determined the crystal...

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Identifiers

PMID: 12598654
DOI: 10.1073/pnas.0436813100
PMCID: PMC151346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.PMID 12598654Read ↗

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