Article
Distinct Mechanisms for Regulating the Tumor Suppressor and Antiapoptotic Functions of Rb
1 May 2003
Abstract excerpt
The retinoblastoma protein, Rb, suppresses tumorigenesis by inhibiting cell proliferation and promoting senescence and differentiation. Paradoxically, Rb also inhibits apoptosis, which would seem to oppose its tumor suppressor function. Further, most human cancer cells inactivate Rb by hyperphosphorylation and demonstrate increased proliferative capacity but not high levels of apoptosis. As a potential...
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