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Article

Dominant negative lptE mutation that supports a role for LptE as a plug in the LptD barrel.

Journal of bacteriology - 1 Mar 2013

Grabowicz Marcin, Yeh Jennifer, Silhavy Thomas J

Abstract excerpt

Lipopolysaccharide (LPS) is the major outer leaflet constituent of the Gram-negative outer membrane (OM) bilayer. A bipartite protein complex of LptD and LptE assembles LPS into the OM. It has been established that LptE assists folding and assembly of its β-barrel partner LptD, yet reported biochemical evidence suggested additional LptE functions. Here, we isolated dominant negative lptE mutations, seeking to...

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Identifiers

PMID: 23316047
DOI: 10.1128/JB.02142-12
PMCID: PMC3591993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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