Article
An induced folding process characterizes the partial-loss of function mutant LptAI36D in its interactions with ligands.
Biochimica et biophysica acta - 1 Oct 2015
Santambrogio Carlo, Sperandeo Paola, Barbieri Francesca, Martorana Alessandra M, Polissi Alessandra, Grandori Rita
Abstract excerpt
Lipopolysaccharide (LPS) is an essential glycolipid of the outer membrane (OM) of Gram-negative bacteria with a tripartite structure: lipid A, oligosaccharide core and O antigen. Seven essential LPS-transport proteins (LptABCDEFG) move LPS to the cell surface. Lpt proteins are linked by structural homology, featuring a β-jellyroll domain that mediates protein-protein interactions and LPS binding. Analysis of...
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