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Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets.

Blood advances - 9 Feb 2021

Stratmann Svea, Yones Sara A, Mayrhofer Markus, Norgren Nina, Skaftason Aron, Sun Jitong, Smolinska Karolina, Komorowski Jan, Herlin Morten Krogh, Sundström Christer, Eriksson Anna, Höglund Martin, Palle Josefine, Abrahamsson Jonas, Jahnukainen Kirsi, Munthe-Kaas Monica Cheng, Zeller Bernward, Tamm Katja Pokrovskaja, Cavelier Lucia, Holmfeldt Linda

Abstract excerpt

Relapse is the leading cause of death of adult and pediatric patients with acute myeloid leukemia (AML). Numerous studies have helped to elucidate the complex mutational landscape at diagnosis of AML, leading to improved risk stratification and new therapeutic options. However, multi-whole-genome studies of adult and pediatric AML at relapse are necessary for further advances. To this end, we performed...

Topics

Cell Cycle Proteins
Child
Genomics
Humans
Leukemia, Myeloid, Acute
Mutation
Precision Medicine
Recurrence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33560403
DOI: 10.1182/bloodadvances.2020003709
PMCID: PMC7876890

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