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Article

TRF2 recruits ORC through TRFH domain dimerization.

Biochimica et biophysica acta. Molecular cell research - 1 Jan 2017

Higa Mitsunori, Kushiyama Tatsunori, Kurashige Seiichiro, Kohmon Daisuke, Enokitani Kouki, Iwahori Satoko, Sugimoto Nozomi, Yoshida Kazumasa, Fujita Masatoshi

Abstract excerpt

Telomeres are specialized chromatin structures that prevent the degradation and instability of the ends of linear chromosomes. While telomerase maintains long stretches of the telomeric repeat, the majority of telomeric DNA is duplicated by conventional DNA replication. A fundamental step in eukaryotic DNA replication involves chromatin binding of the origin recognition complex (ORC). In human cells, telomeric...

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Identifiers

PMID: 27836746
DOI: 10.1016/j.bbamcr.2016.11.004

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TRF2 recruits ORC through TRFH domain dimerization.PMID 27836746Read ↗

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TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stressSemantic proximity Read ↗

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress.Semantic proximity Read ↗

TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere DysfunctionSemantic proximity Read ↗

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage ResponseSemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damageSemantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblastsSemantic proximity Read ↗

Structure of the TRFH Dimerization Domain of the Human Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

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