Article

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress

2021-02-08

Abstract excerpt

Telomeres are intrinsically difficult-to-replicate regions of eukaryotic chromosomes. Telomeric repeat binding factor 2 (TRF2) binds to origin recognition complex (ORC) to facilitate the loading of ORC and the replicative helicase MCM complex onto DNA at telomeres. However, the biological significance of the TRF2-ORC interaction for telomere maintenance remains largely elusive. Here, we employed a separation-of-fu...

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Literature Corpus work: ebaa3524-4758-5eb2-86b3-f342a400682c
DOI: 10.1101/2021.02.08.430303

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