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Article

Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association

1 Apr 2019

Abstract excerpt

Human CTC1-STN1-TEN1 (CST) is an RPA-like single-stranded DNA-binding protein that interacts with DNA polymerase α-primase (pol α) and functions in telomere replication. Previous studies suggest that CST also promotes replication restart after fork stalling. However, the precise role of CST in genome-wide replication remains unclear. In this study, we sought to understand whether CST alters origin licensing and...

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Share to DNA Repair Mechanisms
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Identifiers

PMID: 30979824
DOI: 10.26508/lsa.201800270

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