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Article

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress.

Nucleic acids research - 2 Dec 2021

Higa Mitsunori, Matsuda Yukihiro, Fujii Jumpei, Sugimoto Nozomi, Yoshida Kazumasa, Fujita Masatoshi

Abstract excerpt

Telomeres are intrinsically difficult-to-replicate region of eukaryotic chromosomes. Telomeric repeat binding factor 2 (TRF2) binds to origin recognition complex (ORC) to facilitate the loading of ORC and the replicative helicase MCM complex onto DNA at telomeres. However, the biological significance of the TRF2-ORC interaction for telomere maintenance remains largely elusive. Here, we employed a TRF2 mutant with...

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Identifiers

PMID: 34761263
DOI: 10.1093/nar/gkab1004
PMCID: PMC8643664

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