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Article

Pharmacogenetics of warfarin: development of a dosing algorithm for brazilian patients.

Clinical pharmacology and therapeutics - 1 Dec 2008

Perini J A, Struchiner C J, Silva-Assunção E, Santana I S C, Rangel F, Ojopi E B, Dias-Neto E, Suarez-Kurtz G

Abstract excerpt

A dosing algorithm including genetic (VKORC1 and CYP2C9 genotypes) and nongenetic factors (age, weight, therapeutic indication, and cotreatment with amiodarone or simvastatin) explained 51% of the variance in stable weekly warfarin doses in 390 patients attending an anticoagulant clinic in a Brazilian public hospital. The VKORC1 3673G>A genotype was the most important predictor of warfarin dose, with a partial...

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Source

Identifiers

PMID: 18754001
DOI: 10.1038/clpt.2008.166

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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