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Article

Influence of genetic, biological and pharmacological factors on warfarin dose in a Southern Brazilian population of European ancestry.

British journal of clinical pharmacology - 1 Sept 2011

Botton Mariana Rodrigues, Bandinelli Eliane, Rohde Luis Eduardo Paim, Amon Luis Carlos, Hutz Mara Helena

Abstract excerpt

AIMS: To investigate the influence of polymorphisms in CYP2C9, VKORC1, CYP4F2 and F2 genes on warfarin dose-response and develop a model including genetic and non-genetic factors for warfarin dose prediction needed for each patient. METHODS: A total of 279 patients of European ancestry on warfarin medication were investigated. Genotypes for -1639G>A, 1173C>T, and 3730G>A SNPs in the VKORC1 gene, CYP2C9*2 and...

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Identifiers

PMID: 21320153
DOI: 10.1111/j.1365-2125.2011.03942.x
PMCID: PMC3175513

Genes

VKORC1

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