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Article

Warfarin anticoagulant therapy: a Southern Italy pharmacogenetics-based dosing model.

PloS one - 1 Jan 2013

Mazzaccara Cristina, Conti Valeria, Liguori Rosario, Simeon Vittorio, Toriello Mario, Severini Angelo, Perricone Corrado, Meccariello Alfonso, Meccariello Pasquale, Vitale Dino Franco, Filippelli Amelia, Sacchetti Lucia

Abstract excerpt

BACKGROUND AND AIM: Warfarin is the most frequently prescribed anticoagulant worldwide. However, warfarin therapy is associated with a high risk of bleeding and thromboembolic events because of a large interindividual dose-response variability. We investigated the effect of genetic and non genetic factors on warfarin dosage in a South Italian population in the attempt to setup an algorithm easily applicable in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23990957
DOI: 10.1371/journal.pone.0071505
PMCID: PMC3753327

Genes

VKORC1

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