Article
Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration.
Pharmacogenomics - 1 Jul 2015
Santos Paulo Caleb Junior Lima, Marcatto Leiliane Rodrigues, Duarte Nubia Esteban, Gadi Soares Renata Alonso, Cassaro Strunz Celia Maria, Scanavacca Maurício, Krieger Jose Eduardo, Pereira Alexandre Costa
Abstract excerpt
BACKGROUND: The main aims of the present study were to develop a pharmacogenetic-based warfarin dosing algorithm and to validate it in a highly admixed population. MATERIALS & METHODS: We included two patient cohorts treated with warfarin (first cohort, n = 832; and second cohort, n = 133). RESULTS: Our algorithm achieved a determination coefficient of 40% including the variables age, gender, weight, height,...
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