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Article

Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast.

The Journal of biological chemistry - 2 Dec 2011

Maki Kentaro, Inoue Takahiro, Onaka Atsushi, Hashizume Hiroko, Somete Naoko, Kobayashi Yuko, Murakami Shigefumi, Shigaki Chikako, Takahashi Tatsuro S, Masukata Hisao, Nakagawa Takuro

Abstract excerpt

Mcm2-7 complexes are loaded onto chromatin with the aid of Cdt1 and Cdc18/Cdc6 and form prereplicative complexes (pre-RCs) at multiple sites on each chromosome. Pre-RCs are essential for DNA replication and surviving replication stress. However, the mechanism by which pre-RCs contribute to surviving replication stress is largely unknown. Here, we isolated the fission yeast mcm6-S1 mutant that was hypersensitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21971174
DOI: 10.1074/jbc.M111.285619
PMCID: PMC3308879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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