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Article

Localization of the extracellular end of the voltage sensor S4 in a potassium channel.

Biophysical journal - 1 Apr 2001

Elinder F, Arhem P, Larsson H P

Abstract excerpt

The opening and closing of the pore of voltage-gated ion channels is the basis for the nervous impulse. These conformational changes are triggered by the movement of an intrinsic voltage sensor, the fourth transmembrane segment, S4. The central problem of how the movement of S4 is coupled to channel opening and where S4 is located in relation to the pore is still unsolved. Here, we estimate the position of the...

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Identifiers

PMID: 11259293
DOI: 10.1016/S0006-3495(01)76150-4
PMCID: PMC1301369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Localization of the extracellular end of the voltage sensor S4 in a potassium channel.PMID 11259293Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

Transmembrane movement of the shaker K+ channel S4.Semantic proximity Read ↗

Reduced voltage sensitivity in a K+-channel voltage sensor by electric field remodeling.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

Molecular movement of the voltage sensor in a K channel.Semantic proximity Read ↗

Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac.Semantic proximity Read ↗

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Semantic proximity Read ↗

S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.Semantic proximity Read ↗

The orientation and molecular movement of a k(+) channel voltage-sensing domain.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

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