Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity.

European journal of endocrinology - 1 Nov 2008

Johansson Lovisa E, Lindblad Ulf, Larsson Charlotte A, Råstam Lennart, Ridderstråle Martin

Abstract excerpt

OBJECTIVE: The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis. This study aimed to replicate the association between PNPLA3 variants and obesity, and to investigate their effect on insulin resistance and beta-cell function. METHODS: rs738409 (Met148Ile) and rs2072907 (C to G) were genotyped using TaqMan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Resistance

Share to Insulin Secretion

Share to Membrane Proteins

Share to Obesity

Share to Polymorphism, Genetic

Share to Prevalence

Share to Sweden

Source

Identifiers

PMID: 18728122
DOI: 10.1530/EJE-08-0426

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity.PMID 18728122Read ↗

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins.Semantic proximity Read ↗

Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese childrenSemantic proximity Read ↗

Genetic variance in the adiponutrin gene family and childhood obesity.Semantic proximity Read ↗

Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes.Semantic proximity Read ↗

Variation in the adiponutrin gene influences its expression and associates with obesity.Semantic proximity Read ↗

Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients.Semantic proximity Read ↗

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.Semantic proximity Read ↗

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage.Semantic proximity Read ↗

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.