Article
Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins.
Human molecular genetics - 1 Dec 2009
Kollerits Barbara, Coassin Stefan, Beckmann Noam D, Teumer Alexander, Kiechl Stefan, Döring Angela, Kavousi Maryam, Hunt Steven C, Lamina Claudia, Paulweber Bernhard, Kutalik Zoltán, Nauck Matthias, van Duijn Cornelia M, Heid Iris M, Willeit Johann, Brandstätter Anita, Adams Ted D, Mooser Vincent, Aulchenko Yurii S, Völzke Henry, Kronenberg Florian
Abstract excerpt
Adiponutrin (PNPLA3) is a predominantly liver-expressed transmembrane protein with phospholipase activity that is regulated by fasting and feeding. Recent genome-wide association studies identified PNPLA3 to be associated with hepatic fat content and liver function, thus pointing to a possible involvement in the hepatic lipoprotein metabolism. The aim of this study was to examine the association between two...
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