Article
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
PloS one - 1 Jan 2012
Palmer Colin N A, Maglio Cristina, Pirazzi Carlo, Burza Maria Antonella, Adiels Martin, Burch Lindsay, Donnelly Louise A, Colhoun Helen, Doney Alexander S, Dillon John F, Pearson Ewan R, McCarthy Mark, Hattersley Andrew T, Frayling Tim, Morris Andrew D, Peltonen Markku, Svensson Per-Arne, Jacobson Peter, Borén Jan, Sjöström Lars, Carlsson Lena M S, Romeo Stefano
Abstract excerpt
BACKGROUND: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis. No association between PNPLA3 I148M genotype and T2D in Europeans has been reported. Aim of this study is to examine...
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