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Article

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.

Journal of leukocyte biology - 1 Dec 2008

Elia Angela Rita, Cappello Paola, Puppo Maura, Fraone Tiziana, Vanni Cristina, Eva Alessandra, Musso Tiziana, Novelli Francesco, Varesio Luigi, Giovarelli Mirella

Abstract excerpt

Dendritic cells (DCs) are the most potent antigen-presenting cells and fine-tune the immune response. We have investigated hypoxia's effects on the differentiation and maturation of DCs from human monocytes in vitro, and have shown that it affects DC functions. Hypoxic immature DCs (H-iDCs) significantly fail to capture antigens through down-modulation of the RhoA/Ezrin-Radixin-Moesin pathway and the expression...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18725395
DOI: 10.1189/jlb.0208082

Genes

CCL18
CCL2
CCL20
CXCL1
CXCL10
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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