Article
Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.
Molecular cancer research : MCR - 1 Feb 2008
Ricciardi Annamaria, Elia Angela Rita, Cappello Paola, Puppo Maura, Vanni Cristina, Fardin Paolo, Eva Alessandra, Munroe David, Wu Xiaolin, Giovarelli Mirella, Varesio Luigi
Abstract excerpt
Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues. Dendritic cells (DC) are professional antigen-presenting cells whose differentiation, migration, and activities are intrinsically linked to the microenvironment. DCs will home and migrate through pathologic tissues before reaching their final destination in the lymph node. We studied the differentiation of human monocytes into...
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