Article
Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5'-triphosphate-binding cassette transporters far beyond an efflux pump.
Clinical and experimental immunology - 1 Jun 2013
Lloberas N, Rama I, Llaudó I, Torras J, Cerezo G, Cassis L, Franquesa M, Merino A, Benitez-Ribas D, Cruzado J M, Herrero-Fresneda I, Bestard O, Grinyó J M
Abstract excerpt
This study examines adenosine 5'-triphosphate-binding cassette (ABC) transporters as a potential therapeutic target in dendritic cell (DC) modulation under hypoxia and lipopolysaccharide (LPS). Functional capacity of dendritic cells (DCs) (mixed lymphocyte reaction: MLR) and maturation of iDCs were evaluated in the presence or absence of specific ABC-transporter inhibitors. Monocyte-derived DCs were cultured in...
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