Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.

European journal of immunology - 1 Apr 2013

Pierobon Daniele, Bosco Maria Carla, Blengio Fabiola, Raggi Federica, Eva Alessandra, Filippi Miriam, Musso Tiziana, Novelli Francesco, Cappello Paola, Varesio Luigi, Giovarelli Mirella

Abstract excerpt

DCs are powerful antigen-presenting cells central in the orchestration of innate and acquired immunity. DC development, migration, and activities are intrinsically linked to the microenvironment. DCs migrate through pathologic tissues before reaching their final destination in the lymph nodes. Hypoxia, a condition of low partial oxygen pressure, is a common feature of many pathologic situations, capable of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Inflammation Mediators

Share to Membrane Glycoproteins

Share to Receptors, Immunologic

Share to Th1 Cells

Share to Th17 Cells

Source

Identifiers

PMID: 23436478
DOI: 10.1002/eji.201242709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.PMID 23436478Read ↗

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.Semantic proximity Read ↗

Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.Semantic proximity Read ↗

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.Semantic proximity Read ↗

Hypoxia modulates phenotype, inflammatory response, and leishmanial infection of human dendritic cells.Semantic proximity Read ↗

Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.Semantic proximity Read ↗

Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation.Semantic proximity Read ↗

Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells.Semantic proximity Read ↗

Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype.Semantic proximity Read ↗

Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5'-triphosphate-binding cassette transporters far beyond an efflux pump.Semantic proximity Read ↗

Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation programSemantic proximity Read ↗

Exposure to normobaric hypoxia shapes the acute inflammatory response in human leukocytes in vivoSemantic proximity Read ↗

HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.