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Article

Hypoxia promotes the tolerogenic phenotype of plasmacytoid dendritic cells in head and neck squamous cell carcinoma.

Cancer medicine - 1 Feb 2022

Fan Cui, Wu Jichang, Shen Yilin, Hu Haixia, Wang Quan, Mao Yufeng, Ye Bin, Xiang Mingliang

Abstract excerpt

OBJECTIVE: We aim to review the roles of plasmacytoid dendritic cells (pDCs) in head and neck squamous cell carcinoma (HNSCC) and explore the effects of hypoxia on the tolerogenic transformation of pDCs. BACKGROUND: pDCs, best known as professional type I interferon-secreting cells, play key roles in immune surveillance and antitumor immunity. Recently, pDCs have been shown to be tolerogenic and correlate with...

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Identifiers

PMID: 34964283
DOI: 10.1002/cam4.4511
PMCID: PMC8855917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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