Article
Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells.
Immunology and cell biology - 1 Dec 2005
Qu Xun, Yang Mei-Xiang, Kong Bei-Hua, Qi Lan, Lam Queenie Lai Kwan, Yan Shi, Li Peng, Zhang Min, Lu Liwei
Abstract excerpt
Hypoxia, a prominent characteristic of inflammatory tissue lesions and solid tumour microenvironments, is a crucial stimulus capable of modulating the expression of specific genes involved in leucocyte recruitment. Although studies have shown that hypoxia can affect leucocyte migration by influencing the expression of migration-related genes, such as matrix metalloproteinases (MMP) and their endogenous tissue...
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