Article
Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.
Scientific reports - 1 Sept 2015
Yang Meixiang, Liu Yanguo, Ren Guangwen, Shao Qianqian, Gao Wenjuan, Sun Jintang, Wang Huayang, Ji Chunyan, Li Xingang, Zhang Yun, Qu Xun
Abstract excerpt
A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic stress has broad implications for human diseases. As we previously reported, hypoxia significantly altered dendritic cells (DCs) to a DC2 phenotype and promoted a Th2 polarization of naïve T cells with increased IL-4 production. However,...
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