Article
Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA.
American journal of respiratory cell and molecular biology - 1 Feb 2009
Caci Emanuela, Melani Raffaella, Pedemonte Nicoletta, Yueksekdag Guelnihal, Ravazzolo Roberto, Rosenecker Joseph, Galietta Luis J V, Zegarra-Moran Olga
Abstract excerpt
Na(+) absorption and Cl(-) secretion are in equilibrium to maintain an appropriate airway surface fluid volume and ensure appropriate mucociliary clearance. In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl(-) secretion and...
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