Article
Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.
eLife - 30 May 2022
Saint-Criq Vinciane, Guequén Anita, Philp Amber R, Villanueva Sandra, Apablaza Tábata, Fernández-Moncada Ignacio, Mansilla Agustín, Delpiano Livia, Ruminot Iván, Carrasco Cristian, Gray Michael A, Flores Carlos A
Abstract excerpt
Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thick mucus accumulation. Bicarbonate is critical for correct mucin deployment and there is increasing interest in understanding its role in airway physiology, particularly in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.