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Article

Epithelial sodium channel silencing as a strategy to correct the airway surface fluid deficit in cystic fibrosis.

American journal of respiratory cell and molecular biology - 1 Sept 2013

Gianotti Ambra, Melani Raffaella, Caci Emanuela, Sondo Elvira, Ravazzolo Roberto, Galietta Luis J V, Zegarra-Moran Olga

Abstract excerpt

In the respiratory system, Na(+) absorption and Cl(-) secretion are balanced to maintain an appropriate airway surface fluid (ASF) volume and ensure efficient mucociliary clearance. In cystic fibrosis (CF), this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in the absence of functional CFTR-dependent Cl(-) secretion. The consequences of...

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Identifiers

PMID: 23600628
DOI: 10.1165/rcmb.2012-0408OC

Genes

CFTR

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