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Article

Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.

FEBS letters - 6 Jan 1997

Kunzelmann K, Kiser G L, Schreiber R, Riordan J R

Abstract excerpt

Cystic fibrosis is characterized by an impaired cyclic adenosine 3,5-monophosphate (cAMP) activated Cl- conductance in parallel with an enhanced amiloride sensitive Na+ conductance (ENaC) of the respiratory epithelium. Very recently, acute downregulation of ENaC by the cystic fibrosis transmembrane conductance regulator (CFTR) was demonstrated in several studies. The mechanism, however, by which CFTR exerts its...

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Source

Identifiers

PMID: 9009227
DOI: 10.1016/s0014-5793(96)01414-7

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.PMID 9009227Read ↗

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Cl- interference with the epithelial Na+ channel ENaC.Semantic proximity Read ↗

Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.Semantic proximity Read ↗

CFTR regulation of epithelial sodium channel.Semantic proximity Read ↗

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.Semantic proximity Read ↗

Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.Semantic proximity Read ↗

Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif.Semantic proximity Read ↗

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Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.Semantic proximity Read ↗

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