Article
Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.
FEBS letters - 6 Jan 1997
Kunzelmann K, Kiser G L, Schreiber R, Riordan J R
Abstract excerpt
Cystic fibrosis is characterized by an impaired cyclic adenosine 3,5-monophosphate (cAMP) activated Cl- conductance in parallel with an enhanced amiloride sensitive Na+ conductance (ENaC) of the respiratory epithelium. Very recently, acute downregulation of ENaC by the cystic fibrosis transmembra...
Topics
- 1-Methyl-3-isobutylxanthine
- Amiloride
- Animals
- Cystic Fibrosis Transmembrane Conductance Regulator
- Cytoplasm
- Down-Regulation
- Genes, Reporter
- Humans
- Meglumine
- Mutation
- Patch-Clamp Techniques
- Phosphodiesterase Inhibitors
- Rats
- Recombinant Fusion Proteins
- Sodium
- Sodium Channel Blockers
- Sodium Channels
- Transformation, Genetic