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Article

Sustained inhibition of ENaC in CF: Potential RNA-based therapies for mutation-agnostic treatment.

Current opinion in pharmacology - 1 Jun 2022

Kota Pradeep

Abstract excerpt

Disruption of the equilibrium between ion secretion and absorption processes by the airway epithelium is central to many muco-obstructive lung diseases including cystic fibrosis (CF). Besides correction of defective folding and function of CFTR, inhibition of amiloride-sensitive epithelia sodium channels (ENaC) has emerged as a bona fide therapeutic strategy to improve mucociliary clearance in patients with CF....

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Identifiers

PMID: 35483215
DOI: 10.1016/j.coph.2022.102209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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