Article

New Generation ENaC Inhibitors Detach Cystic Fibrosis Airway Mucus Bundles via Sodium/Hydrogen Exchanger Inhibition

2020-10-27

Abstract excerpt

<h4>Background: </h4> and Purpose: Cystic fibrosis (CF) is a recessive inherited disease caused by mutations affecting anion transport by the epithelial ion channel cystic fibrosis transmembrane conductance regulator (CFTR). The disease is characterized by mucus accumulation in the airways and intestine, but the major cause of mortality in CF is airway mucus accumulation, leading to bacterial colonization, inflamm...

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Literature Corpus work: fde5c8a1-0dcc-5f91-966c-0a6715e5f5fe
DOI: 10.22541/au.160382895.53449293/v1

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