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Article

Transgenic hCFTR expression fails to correct β-ENaC mouse lung disease.

American journal of physiology. Lung cellular and molecular physiology - 15 Jan 2012

Grubb B R, O'Neal W K, Ostrowski L E, Kreda S M, Button B, Boucher R C

Abstract excerpt

The relationships between airway epithelial Cl(-) secretion-Na(+) absorption balance, airway surface liquid (ASL) homeostasis, and lung disease were investigated in selected transgenic mice. 1) To determine if transgenic overexpression of wild-type (WT) human CFTR (hCFTR) accelerated Cl(-) secretion and regulated Na(+) absorption in murine airways, we utilized a Clara cell secretory protein (CCSP)-specific...

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Source

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Identifiers

PMID: 22003093
DOI: 10.1152/ajplung.00083.2011
PMCID: PMC3349361

Genes

ASL
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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