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Article

Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse.

American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2008

Randrianarison Nadia, Clerici Christine, Ferreira Chrystophe, Fontayne Alexandre, Pradervand Sylvain, Fowler-Jaeger Nicole, Hummler Edith, Rossier Bernard C, Planès Carole

Abstract excerpt

Transepithelial alveolar sodium (Na+) transport mediated by the amiloride-sensitive epithelial sodium channel (ENaC) constitutes the driving force for removal of fluid from the alveolar space. To define the role of the beta-ENaC subunit in vivo in the mature lung, we studied a previously established mouse strain harboring a disruption of the beta-ENaC gene locus resulting in low levels of beta-ENaC mRNA...

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Identifiers

PMID: 18024719
DOI: 10.1152/ajplung.00307.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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