Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.

doi:10.1016/j.cbpc.2008.07.013

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Article

Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Mar 2009

Hobbie Kristen R, Deangelo Anthony B, King Leon C, Winn Richard N, Law J McHugh

Abstract excerpt

Recent changes in the risk assessment landscape underscore the need to be able to compare the results of toxicity and dose-response testing between a growing list of animal models and, quite possibly, an array of in vitro screening assays. How do we compare test results for a given compound between vastly different species? For example, what dose level in the ambient water of a small fish model would be...

Topics

Animals
Animals, Genetically Modified
Carcinogens
DNA
DNA Adducts
Dimethylnitrosamine
Dose-Response Relationship, Drug
Guanine
Immunohistochemistry
Liver
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutagenicity Tests

Mutation

Oryzias

Random Allocation

Rats

Rats, Inbred F344

Source

Open in PubMed

Identifiers

PMID: 18722551
DOI: 10.1016/j.cbpc.2008.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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