Article
DNA adducts: biological markers of exposure and potential applications to risk assessment.
Mutation research - 1 Sept 1996
La D K, Swenberg J A
Abstract excerpt
DNA adducts have been investigated extensively during the past decade. This research has been advanced, in part, by the development of ultrasensitive analytical methods, such as 32P-postlabeling and mass spectrometry, that enable detection of DNA adducts at concentrations as low as one adduct per 10(9) to 10(10) normal nucleotides. Studies of mutations in activated oncogenes such as ras, inactivated tumor...
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