Article
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α.
FEBS letters - 3 Jan 2014
Ganesh Karuna, van Maldegem Febe, Telerman Stephanie B, Simpson Paul, Johnson Christopher M, Williams Roger L, Neuberger Michael S, Rada Cristina
Abstract excerpt
CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-α. CTNNBL1 comprises a HEAT-like domain (including a nuclear export signal), a central armadillo domain, and a coiled-coil C-terminal...
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