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Article

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate.

PLoS biology - 1 Jul 2004

Arakawa Hiroshi, Saribasak Huseyin, Buerstedde Jean-Marie

Abstract excerpt

Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation. To investigate how AID can alternatively induce recombination or hypermutation, psiV gene deletions were introduced into the rearranged light chain locus of the DT40...

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Source

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Identifiers

PMID: 15252444
DOI: 10.1371/journal.pbio.0020179
PMCID: PMC449846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate.PMID 15252444Read ↗

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.Semantic proximity Read ↗

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