Article
Influence of genotyping error in linkage mapping for complex traits--an analytic study.
BMC genetics - 25 Aug 2008
Lebrec Jérémie J P, Putter Hein, Houwing-Duistermaat Jeanine J, van Houwelingen Hans C
Abstract excerpt
BACKGROUND: Despite the current trend towards large epidemiological studies of unrelated individuals, linkage studies in families are still thoroughly being utilized as tools for disease gene mapping. The use of the single-nucleotide-polymorphisms (SNP) array technology in genotyping of family data has the potential to provide more informative linkage data. Nevertheless, SNP array data are not immune to...
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