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Article

Using linkage genome scans to improve power of association in genome scans.

American journal of human genetics - 1 Feb 2006

Roeder Kathryn, Bacanu Silvi-Alin, Wasserman Larry, Devlin B

Abstract excerpt

Scanning the genome for association between markers and complex diseases typically requires testing hundreds of thousands of genetic polymorphisms. Testing such a large number of hypotheses exacerbates the trade-off between power to detect meaningful associations and the chance of making false discoveries. Even before the full genome is scanned, investigators often favor certain regions on the basis of the...

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PMID: 16400608
DOI: 10.1086/500026
PMCID: PMC1380233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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