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Article

Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model

15 Aug 2008

Abstract excerpt

Classic but also novel roles of p53 are becoming increasingly well characterized. We previously showed that ex vivo retroviral transfer of mitochondrially targeted wild type p53 (mitop53) in the Emu-myc mouse lymphoma model efficiently induces tumor cell killing in vivo. In an effort to further explore the therapeutic potential of mitop53 for its pro-apoptotic effect in solid tumors, we generated...

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PMID: 18719383
DOI: 10.4161/cc.7.16.6070

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