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Adenovirus p53 gene therapy

22 Dec 2005

Abstract excerpt

To date, dysfunctional tumour suppressor genes are the most common genetic lesions identified in human cancers. Functional copies of tumour suppressor genes can be introduced into cancer cells by gene transfer using adenoviral vectors. This approach has been extensively studied in the clinic with intratumoural injection of a replication-defective adenovirus that expresses p53 (Ad-p53). Overexpression of p53 in...

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PMID: 16370914
DOI: 10.1517/14712598.6.1.55

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