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Article

The Mitochondrial Protein MAVS Stabilizes p53 to Suppress Tumorigenesis.

Cell reports - 21 Jan 2020

Zhang Wanchuan, Gong Jing, Yang Huan, Wan Luming, Peng Yumeng, Wang Xiaolin, Sun Jin, Li Feng, Geng Yunqi, Li Dongyu, Liu Ning, Mei Gangwu, Cao Yuan, Yan Qiulin, Li Huilong, Zhang Yanhong, He Xiang, Zhang Qiaozhi, Zhang Rui, Wu Feixiang, Zhong Hui, Wei Congwen

Abstract excerpt

Recent reports have shown the critical role of the mitochondrial antiviral signaling (MAVS) protein in virus-induced apoptosis, but the involvement of MAVS in tumorigenesis is still poorly understood. Herein, we report that MAVS is a key regulator of p53 activation and is critical for protecting against tumorigenesis. We find that MAVS promotes p53-dependent cell death in response to DNA damage. MAVS interacts...

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Identifiers

PMID: 31968249
DOI: 10.1016/j.celrep.2019.12.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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