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Article

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006

Wang Wenge, Kim Seok-Hyun, El-Deiry Wafik S

Abstract excerpt

p53 deficiency is common in almost all human tumors and contributes to an aggressive chemo- or radiotherapy-resistant phenotype, therefore providing a target for drug development. Molecular targeting to restore wild-type p53 activity has been attempted in drug development and has led to the identification of CP-31398, PRIMA1, and the Nutlins. However, strategies targeting p53-activated transcriptional responses...

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Source

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Identifiers

PMID: 16835297
DOI: 10.1073/pnas.0604507103
PMCID: PMC1544164

Genes

PRIMA1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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