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Targeting p53 to mitochondria for cancer therapy

1 Jul 2008

Abstract excerpt

Although the tumor suppressor protein p53 is a major senescence- and cell death-inducing transcription factor, recent work has clearly demonstrated that p53 has additional, extranuclear effects that contribute to its cell cycle-arresting and proapoptotic functions. Mitochondrial outer membrane permeabilization (MOMP) is (one of) the most prominent apoptotic checkpoint(s), and cytoplasmic p53 can induce MOMP by...

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PMID: 18642442
DOI: 10.4161/cc.7.13.6222

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