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Advances in adenovirus-mediated p53 cancer gene therapy

10 Oct 2013

Abstract excerpt

INTRODUCTION: The tumor suppressor p53 gene regulates diverse cellular processes, such as cell-cycle arrest, senescence, apoptosis and autophagy, and it is frequently inactivated by genetic alterations in ∼ 50% of all types of human cancers. To restore wild-type p53 function in p53-inactivated tumors, adenovirus-mediated p53 gene therapy has been developed as a promising antitumor strategy in preclinical...

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PMID: 24107178
DOI: 10.1517/14712598.2013.845662

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